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HERBAL REMEDIES FOR ANKYLOSING SPONDYLITIS

What is Ankylosing spondylits ?

Ankylosing spondylitis is one of the rheumatic disease, which is a chronic, inflammatory that causes arthritis of the spine and sacroiliac joint - the joint at the base of the spine where the spinal column joins the pelvis."Ankylosis" means the fusion of verterae to each other. The vertebrae fuse together because of thechronic inflammation and irritation of the spinal joints. Ankylosis is a debilitating condition that can cause decreased range of movement in the spine and loss of spinal mobility and function, thereby, severely impact a person's quality of life. Ankylosis can spread to other joints as well since Ankylosing spondylitis is a systemic rheumatic disease, it can lead to inflammation in other parts of the body such as the joints of the hips, knees, or shoulders.

Ankylosing spondylitis - According to Ayurveda

The explanation of Ankylosing spondylitis may seem weird to modern world people but Ayurveda is an ancient healing science utilizing herbs for centuries and still in practice. According to Ayurveda, Rheumatic pains are due to formation of toxins in the body called "Ama". According to modern science, these toxins can be corelated with auto-antibodies which are body's own defence system destroying body's own tissues. These toxins are known as "aama" in Ayurvedic terminology. So the concept of treating Ankylosing spondylitis is digesting the " aama" by giving herbs like Curcumin, Aamvatantak Churna, etc. Controlling the vata is also very important, after clearing the "Aama". Vata- the kinetic energy of the body is regulated by regular massage with Ayurvedic oils, internal consumption of medicated Cow's ghee with anti-inflammatory herbal tablets like Sinhnaad Guggul, Swarn Guggul (Guggul with Gold), Kaishore Guggul and any formulation containing Guggul like Joint Aid Plus capsules . Herbal products like Aam vatantak Churna can be used for digestion of "aama" and together with Joint Aid Plus is useful in managing pain and inflammation. Punarnava mandoor tablets are useful in reducing inflammatory edema around the joints and also helps in rebuilding the strength.

Sometimes the pain is quiet acute in ankylosing spondylitis. This pain painful condition in Ankylosing spondylitis and inflammation needs to be tackled quickly. So the herbal combination of various herbs which work instantly for painful joints is given.

There are very common herbs for painful joints which work insantly. The herbs are like Dry Ginger, Guggul, Turmeric (curcumin), Fenugreek, Ashwagandha, Sallaki (Boswellia), and Giloy (Tinospora). The extracts of these herbs are more effective in reducing the pain and inflammation of all types of arthritis and joint pains. Our product Joint aid plus contains herbal extracts of such herbs which are useful in painful joint conditions.

Constipation must be avoided at all costs in Ankylosing spondylitis. Constipation leads to vitiation of Vata, which may increase bouts of increased pain.

Herbal remedies for Ankylosing Spondylitis - Recommended by Dr. Vikram Chauhan MD (Ayurveda)

Rheumatoid Arthritis Care Pack

Rheumatoid Arthritis Care Pack

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Dosage

  1. Cap. Joint Aid Plus - 2 cap. twice daily ( 2 Bottles )
  2. Cap. Boswellia Curcumin - 2 cap. twice daily ( 2 Bottles )
  3. Ashwagandha Capsules - 2 twice daily ( 2 Bottles )
  4. Aamvatantak Churna - 1 teaspoonful twice daily, 1 hr. after meals ( 2 jars of 100 gm each)

Causes of Ankylosing Spondylitis

Video - Boswellia Curcumin

The exact cause of Ankylosing Spondylitis is not known however, research has demonstrated that this tends to run in families. Although there is evidence for a possible genetic predisposition to this disease is that a specific Human Leukocyte Antigen (HLA) tissue type called HLA-B27 occurs in about 90% of individuals with Ankylosing Spondylitis.

Ankylsoing spondylitis

is more prevalent among men than in women. Most of the patients are generally young men in the age group of 20 to 35 years and 60 to 70 % patients are generally men.

There are many herbs for Ankylosing spondylitis

These herbs are useful in all types of arthritis like osteoarthritis, rheumatoid arthritis and other forms of inflammatory joint conditions. Some of them reduce the pain, some reduce inflammation while herbs like Giloy (Tinospora and Ashwagandha ) are helpful in many other autoimmune disorders as well.

Nirgundi (Vitex negundo)

Vitex negundo is described in Ayurveda as one of the most potent natural anti-arthritic herbs. It is very effective in controlling pain and inflammation particularly in arthritis and sciatica patients. This is a very useful herbal remedy for ankylosing spondylitis.

Shallaki (Boswellia serrata)

Boswellia serrata is a very popular natural anti-inflammatory herb used by Ayurveda physicians all over the world. It is commonly known in India as ‘Salai Guggul'. The resin obtained from the tree is purified and then used for pain and inflammation.It relieves arthritis pain naturally without causing any side effects . This is a very effective natural remedy for ankylosing spondylitis.

Guggul (Commiphora mukul)

Commiphora mukul is a known anti-inflammatory agent used by Ayurveda physicians worldwide. It not only helps in inflammation but also helps in arresting the progress of ankylosing spondylitis. The analgesic and anti-inflammatory action is almost immediate. Guggul is also used in weight loss formulas and is effective in reducing weight, thus helping osteoarthritis patients directly and indirectly. It also reduces blood cholesterol levels.

Sonth (Zingiber officinale)

It is commonly known as dry ginger. Dry Ginger is another useful anti-inflammatory herb. It also improves appetite and good for digestive and respiratory system. Dry ginger remarkably reduce markers of inflammation in the blood and is a very potent analgesic.

Giloy (Tinospora cordifolia)

Tinospora is considered as one of the leading immuno-modulator. In Ayurveda, this herb is known as “Amrita”. Amrit literally means “elixir for long life span”. Recent studies explains it is useful in auto-immune disorders especially Rheumatoid arthritis and gout.

Ashwagandha (Withania somnifera)

Ashwagandha is popularly known as Indian ginseng in the west. It has known anti-inflammatory, anti-cancer and anti-stress activities. The plant steroids exert anti-inflammatory action where as another active ingredient of this herb root is Withaferin, Which act as a potent stress buster. It's very useful herbal remedy for ankylosing spondylitis.

Joint Aid Plus - An effective Herbal remedy for Arthritis & Pains

Joint Aid Plus is a blend of unique herbs described in Ayurveda as best anti-inflammatory herbs. These rare herbs are nature's answer to moderate to severe forms of inflammation, swelling and pain. Joint Aid Plus contains extracts of Nirgundi, Shallaki, Guggul, Ginger, Giloy and Ashwagandha. These herbs act together in a synergistic manner and control acute and chronic inflammatory reactions.

Herbs in Joint Aid Plus: Joint Aid Plus is purely a herbal formulation without any chemicals added into it. The ingredients are frequently used in Ayurvedic system of medicine since 5,000 B.C. without any side effects.

 

Price: $ 22.95    |  Quantity : 60 Veg Caps   |   Buy Now!    |      Larger View

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$ 22.95

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$ 45.90

$ 42.95

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Ingredients in Joint Aid Plus

(Capsules Joint Aid Plus contains pure herbs for Arthritis, explained above)

S. No.

Herb Used

Latin Name

Quantity

1.

Nirgundi

Vitex negundo

100 mg

2

Shallaki

Boswellia serrata

200 mg

3.

Guggul

Commiphora mukul

200 mg

4.

Sonth

Zingiber officinale

25 mg

5.

Giloy

Tinospora cordifolia

50 mg

6.

Ashwagandha

Withania somnifera

25 mg

Other Herbal remedies for Ankylosing Spondylitis

There are so many other useful herbal remedies for Ankylosing Spondylitis which give excellent results in joint pains and inflammation. These herbal remedies are also effective in many other forms of arthritis.

Herbal remedies for Osteoarthritis, Ankylosing Spondylitis, Psoriatic Arthritis Cervical Spondylitis, Sacroileitis, Paget's disease and other painful joint conditions

Commiphora mukul is a very unique and powerful anti-inflammatory herb and is very effective in all types of arthritis. Some of the tablets containing this herb are mentioned below. These herbal tablets are purely classical herbal remedies for arthritis and are used in Ayurveda since ages.

1. Punarnava Mandoor

These herbal tablets contain Boerrhavia diffusa which reduces the inflammation remarkably. It removes excess body fluid through kidneys. It strengthens immune system and improves haemoglobin levels. It contains the natural iron. The tablets are useful in inflammatory Ankylosing spondylitis and rheumatoid arhritis, which is usually associated with anemia. These tablets should be used along with aamvatantak churna, yograj guggul and syrup Kumari Saar (Kumari saar is pure aloe vera juice)

2. Curcumin Capsules

This is another natural remedy for ankylosing spondylitis. This helps in inflammation quickly. It is very useful in all auto-immune diseases.

1. Curcumin capsules
2. Punarnava mandur tablets
3. Aamvatantak churna
4. Joint aid plus

WHY THESE 4 PRODUCTS SHOULD BE USED TOGETHER IN ANKYLOSING SPONDYLITIS ?

The patient should consume the 4 products together rather than only 1 joint aid plus or Curcumin ?

The reason is that all work in a synergistic manner to work at various levels.

To relieve joint pains, these products work as anti-inflammatory drugs.. without causing any side effects, especially the product Joint aid plus.

The other product Curcumin is a stronger anti-inflammatory which potentiates the efficacy of joint aid plus.

That's why it is being use along with Joint aid plus.

We do not use any chemicals in our products.. Since herbs are very mild in nature and that's why we have to use them all together.

There is a disease modifying agent herbal formula called - Aam vatantak churna.

Aam in Ayurveda means endotoxins. The auto-immune diseases like Rheumatoid arthritis, ankylosing spondylitis are because of endotoxins formation in our bodies. These endotoxins are intermediate metabolites or produced by faulty metabolism of the immune system. This results in faulty anti-bodies destroying our own tissues. This is Aam according to Ayurveda.

The powder aam vatantak churna is a mixture of various herbs which modify the immune response thereby helping in modifying the disease, arresting its progress and even reversing it in some cases. so use of this product is also recommended.

The 4th product in the combination is Punarnava mandur. Literal meaning of Punar in ancient Indian laguage is "Again" and "Nava" means New.

So Punar nava means - New Again.

it helps to renew the body again. it rejuvenates the cells. Renews the whole system and helps to get rid of toxins from the body. It eases out the pressure from the system. punarnava is a herb called - Boerrhavia diffusa which is used worldwide to clear the toxins and excessive fluid from the body. It helps to reduce body weight and also get rid of swelling around joints. Therefore it has a different action than other herbs in this combination. That's why these 4 products are used together to get maximum benefit in painful, inflammed, swollen joints

Aam-Vaat-Antak Churna

(Herbs for Rheumatoid Arthritis and Ankylosing Spondylitis)

AamVaat Antak Churna is a blend of unique herbs for arthritis and described in Ayurveda as best anti-inflammatory, detoxifying herbs. Aama is considered as root cause of Rheumtism and ankylosing spondylitis in Ayurveda.Various herbs in this herbal powder naturally clear away the toxins i.e. Aama. These rare herbs are nature's answer to moderate to severe forms of inflammation, swelling and pain. This herbal powder contains Ashwagandha, Fenugreeki, Suranjan, Tinospora, Gorakhmundi and Sonth. These herbs act together in a synergistic manner and control acute and chronic pain in joints.

Herbs in Aam-Vaat-Antak Churna : AamVaat Antak Churna is purely a herbal formulation without any chemicals added into it.It contains very effective herbs for Rheumatoid arhtirits and joint pains. The ingredients are frequently used in Ayurvedic system of medicine since 5,000 B.C.It is a very effective herbal remedy for Rheumatoid arthritis and every other form or arthritis without any side effects.

Price: $ 22.95    |  Quantity : 200 gm   |   Buy Now!    |    Larger View

Description

Price

Sale Price

Shipping

Order Now

1 Bottle

$ 22.95

$ 22.95

Standard

Buy Now

2 Bottles

$ 45.90

$ 42.95

Standard

Buy Now

3 Bottles

$ 68.85

$ 61.95

Standard

Buy Now

5 Bottles

$ 114.75

$ 97.95

Standard

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10 Bottles

$ 229.50

$ 183.95

Express

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Ingredients

S. No.

Herb Used

English Name

Latin Name

Parts Used

Quantity

1.

Ashwagandha

Winter Cherry

Withania somnifera

Roots

60 gm

2

Methi

Fenugreek

Trigonella foenum graecum

Seeds

20 gm

3.

Suranjaan

Autumn crocus

Colchicum automnale

Roots

40 gm

4.

Gorakhmundi

Rice field weed

Sphaeranthus indicus

Whole

30 gm

5.

Giloy

Tinospora

Tinospora cordifolia

Stem

30 gm

6.

Sonth

Dry ginger

Zingiber officinale

Rhizome

20 gm

Ashwagandha-Winter Cherry (Withania somnifera): Ashwagandha is adaptogenic, relieves anxiety and stress. It is also an effective anti-inflammatory. Ashwagandha is a useful herb especially for diabetic neuropathy, weakness, fatigue and weight loss due to diabetes. It improves overall well being. It has been used in Ayurveda for ‘Vata and Kapha' disorders. It is very much effective in swollen joints, inflammatory conditions of joints.Ashwagandha is very useful herbal remedy for Rheumatoid arhtirits

Methi- Fenugreek (Trigonella-foenum-graecum): Fenugreek has multiple uses as it not only causes remission in inflammatory and painful joint conditions but also a useful method to control pain due to ‘Vata'. Regular use of leaves of this plant also controls blood sugar levels very effectively.

Suranjan-Automn Crocus (Colchicum automnale): Ayurveda utilizes this herb for painful joints swollen due to imbalance in uric acid metabolism. This herb is a source of drug ‘Colchicine' used in modern medicine for decreasing uric acid production.

Gorakhmundi (Rice Field Weed): It is a very effective herb for regularizing the uric acid metabolism. This plant can also help to cure weak vital power, gaseous problems, enlargement of spleen as well as painful joints.

Giloy (Tinospora cordifolia): This is a twine that wraps around many trees. This miraculous herb is useful in many auto-immune disorders like Rheumatoid Arthritis. It has immunomodulatory effect and improves our immune system and immune response to antigens. It improves body's defense mechanisms. It gives new life to dying brain cells and rejuvenates the whole body. It is best anti-cancer, immunomodulator and memory enhancing herb.

Sonth (Zingiber officinale): Commonly known as ‘Dry Ginger' is a very useful ‘ama' removing or detoxifying herb. It is a potent pain killer as well as anti-inflammatory herb.

Home Remedies For Ankylosing spondylitis

  1. Use Ginger, Black Pepper or any good digestive with your meals. It will help detoxify your body.
  2. 1 tablespoonful of Turmeric should be consumed once everyday, after boiling it in milk for half an hour.
  3. Constipation must be avoided at all costs. Constipation may increase pain in Ankylosing spondylitis.
  4. Herbs have divine healing powers and they have the ability to cure any disease from the root. They were gifted to us by God when he created life. So believe in God if you want to get rid of your problems !
  5. Ayurvedic herbs are unique natural remedies for Ankylosing spondylitis. Ayurvedic principles are different in many ways from modern medicine for example - Drinking water from a copper pan after keeping it overnight is also very useful in Rheumatoid arthritis and Ankylosing spondylitis.
  6. Consuming castor oil at night with milk or alone is a very useful herbal remedy for arthritis, especially rheumatoid arthritis and ankylosing spondylitis.
  7. Improve your nutrition as first step.It plays important role to fight diseases. When nothing works, nutrition works a lot !
  8. Use herbal juices like Aloe vera juice (Kumari Saar) and Amla Juice ( Amla Saar) in routine. Amla is the richest source of natural Vitamin C. Vitamin C improves the natural immunity of the body. 100 gm of Amla juice contains 30 times more vitamin C than 100 gm of oranges.

Expanding the Research Horizon in Ankylosing Spondylitis - Understanding the Role of HLA-B27

By Robert A. Colbert, MD, PhD

Most patients with ankylosing spondylitis (AS) recognize HLA-B27 as a genetic marker that they carry. Indeed, it is found in the vast majority (90-95%) of patients with this disease, compared to less than one of ten healthy people. It is inherited from one parent, and in rare cases both, and is often accompanied by the knowledge that someone else in the extended family has AS or another HLA-B27-associated disease. We also know that HLA-B27 does not work alone. Several additional genes contribute to AS, and major efforts in North America and around the world are dedicated to finding the location of these genes in the human genome. What is often less well appreciated is that HLA-B27 is already a major focus of research, and understanding its role in disease will provide a key piece to this puzzle. Since the discovery of the HLA-B27 - AS connection over 30 years ago, we have learned a great deal about what HLA-B27 does; unfortunately, this has not answered the question of how it causes disease. Recently, new research has uncovered some very unusual features of HLA-B27, and the paradigm has begun to shift toward the idea that an abnormal property of HLA-B27 may be the basis for its connection with disease.

HLA-B27 - a carrier of peptides

What does HLA-B27 do? The product of the HLA-B27 gene is a member of a family of proteins called human leukocyte antigens (HLA) that have an important role in the immune system. T cells are a type of white blood cell that recognize HLA-B27 and decide whether to react to it or ignore it, depending on its shape or surface contour, which in turn depends on the type of peptide it carries. Peptides are small bits of proteins that are produced when the proteins are broken down. The peptides can come either from proteins that our own body makes (self-peptides), or from microbes like viruses or bacteria (foreign peptides). Normally T cells ignore self-peptides and react to foreign peptides, producing chemicals called cytokines that cause an inflammatory reaction. The ability of T cells to recognize and react to foreign peptides carried by HLA proteins is one means that our immune system uses to fight off infections. We know that HLA-B27 works as well as, or perhaps even better than other HLA proteins in helping to fight off viral infections. For example, people with HLA-B27 who have become infected with HIV tend to stay healthy longer than others, and also infection with the hepatitis C virus tends to be cleared more completely. Why this occurs is not known.

For a long time it was thought that people with HLA-B27 developed AS because their T cells were fooled into thinking that the self-peptides carried by HLA-B27 were really foreign peptides. This idea was called 'molecular mimicry', based on the notion that HLA-B27 self-peptides mimicked foreign peptides more often than for other HLA-B proteins. Despite the attractiveness of this idea, is it has been very difficult to find T cells that react against HLA-B27 and its self-peptides (autoreactive T cells). Furthermore, in animal models where HLA-B27 causes an inflammatory disease like AS, there is solid evidence that this idea is not correct.

HLA-B27 - a protein that misfolds

If the peptides carried by HLA-B27 do not cause AS, what does? Several years ago scientists began to look for another explanation. Examining HLA-B27 from a different perspective, they discovered that in addition to its normal activity of carrying peptides, it also has at least two abnormal properties. One is a tendency for the protein to 'misfold' and the second is that it can form an unusual structure called a 'dimer' where two HLA-B27 proteins are attached to one another. Both of these findings suggested alternatives to the notion that the peptides were the key to understanding the role of HLA-B27 in AS.

What is protein misfolding?


One of the most striking examples of protein misfolding is what happens when you boil an egg. Proteins in the egg 'white' and yolk become irreversibly denatured or misfolded, to the point where the process can never be reversed. (Ever try to unboil an egg?) Over the last several years there has been increasing recognition that a number of genetic diseases result from protein misfolding. However, the symptoms of the disease, and the abnormal processes that cause these symptoms, can be quite varied and depend on many factors. For example, proteins that misfold just after being made are often broken down very quickly, and as a result the protein is missing and not available to do its job. This is known to occur in certain types of hemophilia (bleeding disorder). When misfolded proteins are not eliminated quickly and build up in tissues outside the cell, they can also wreak havoc by preventing other cells from carrying out their function or even to die. This is important in certain neurological diseases including Alzheimer's.

HLA-B27 misfolding and the unfolded protein response
We are just beginning to learn more about the implications of HLA-B27 misfolding. First, since protein misfolding can be a little complicated, it's worth a more complete explanation. The story begins inside the cell, in a compartment known as the endoplasmic reticulum (ER). HLA-B27 is made here, and stops long enough to pick up its peptide cargo before delivering it to the cell surface. In order to carry this cargo, it needs to fold into a certain shape that allows the peptide to fit. It seems that this is where the problem is - HLA-B27 doesn't get into shape very well. There are a lot of other proteins that try to help, but if there aren't enough or they aren't working well, HLA-B27 tends to accumulate. This is a particular problem when the cell is trying to make a lot of HLA-B27 such as during an infection or an immune response. These incompletely folded (and/or misfolded) HLA-B27 proteins can cause ER 'stress'. This in turn activates a series of complex events that result in an 'unfolded protein response' (UPR). The UPR increases the assembly line machinery responsible for folding and secreting proteins, and also the capacity to break down proteins that have misfolded, and is one way that the cell adapts to ER stress.

A surprising finding has been that the UPR seems to have additional effects in immune cells. When the UPR is activated, certain immune cells 'over-respond' to products that come from bacteria and viruses. Some of the overproduced cytokines not only promote inflammation, but are also linked to increased bone formation. This could be important in AS, since another aspect of this disease that is not understood is the tendency to form too much bone in certain places and too little bone in others. There are many studies underway to better define how HLA-B27 misfolding may be important in the development of AS.

Abnormal forms of HLA-B27 In addition to misfolding, the formation of HLA-B27 dimers on the cell surface also has possible implications. We have learned that 'natural killer' or NK cells, in addition to T cells, can recognize HLA proteins. NK cells use a different type of 'receptor' that may be able to selectively recognize HLA-B27 dimers in addition to the traditional forms on the cell surface. NK cells are one of the first lines of defense used by the immune system, and if recognition of the abnormal HLA-B27 dimers changes their function, this could contribute to a chronic inflammatory disease.

Summary

As we gained a more complete knowledge of what HLA-B27 does during the 1980s and 1990s, there was a strong sense that we were only a few years from understanding its role in AS. This was bolstered by the development of animal models where HLA-B27 and the immune system could be manipulated to test various ideas and perhaps even be used to discover better treatments. Although these goals have not yet been realized, there is a renewed optimism that this puzzle can be solved. The discovery of additional genes that contribute to AS will be important as the function of their gene products should inform us on the role of HLA-B27, and may identify additional approaches to treat the disease.
 

 

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