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Chronic kidney disease is a condition of kidneys that is characterized by a progressive loss kidney function, which results in kidney failure.
Healthy kidneys remove excess wastes and fluids from the body. In case of chronic kidney disease, there is a gradual impairment of this function performed by the kidneys.
GFR or Glomerular filtration rate is the measure of the normal rate at which the kidneys filter blood every minute.
The normal glomerular filtration rate is 60 ml/min.
A GFR below this value for a continuous period of 3 months is a sign of renal impairment.
|Stage 1||Hypertension, Urinary infections and abnormal urine analysis||90 or above||Normal kidney function|
|Stage 2||Same as in stage 1||60 - 89||Impaired kidney function with mild Decline in G.F.R.|
|Stage 3||Low blood cells, tingling and numbness, bone pain||30 – 59||Moderate decline in G.F.R.|
|Stage 4||Severe complications like Anemia Uremia, Anemia, malnutrition,||15 -29||Severe decline in G.F.R|
|Stage 5||Hyperparathyroidism, Swelling in the hands, legs, eyes, lower back, shortness of breath||< 15||Kidney failure|
Diabetes is one of the major causes why people develop renal impairment.
In the initial stages, small albumin proteins seep through the damaged kidneys in urine. Later on, there occurs heavy proteinuria as larger proteins are lost through the kidneys. In addition to this, there is a persistent reduction in the glomerular filtration rate as well.
Diabetes affecting kidney function is technically called as "Diabetic nephropathy".
High blood pressure is a force which the blood exerts on the arterial walls.
In patients of hypertension, the kidneys receive blood at a pressure that is above normal blood pressure values.
Because of this, small capillaries supplying the different parts of the kidneys get damaged and result in renal impairment.
As a result, the excess fluids accumulate in the kidneys and build up blood pressure, all the more.
Patients of kidney failure are unable to manufacture erythropoietin hormone that is critical for the formation of RBCs.
In case of kidney failure, the kidneys are no longer able to sufficiently filter out excess fluid and waste metabolites from the body.
In such patients, the waste metabolites and excess water are artificially removed from the blood with the help of a dialyzer (a mechanical device).
It is mainly of two types – Hemodialysis and peritoneal dialysis.
When the kidneys fail to maintain the electrolyte imbalance in the body and there are raised urea and creatinine levels in blood, the ultimate option to manage kidney failure is dialysis and eventually a kidney transplant.
Kidney transplant is the ultimate treatment for patients having severely impaired kidney function.
Dialysis is a very tedious procedure and the patient experiences a lot of discomfort going for frequent sittings of dialysis.
Another problem is the huge expenses associated with every dialysis sitting which are not feasible for every kidney patient.
Owing to all these inconveniences, kidney transplant becomes inevitable for kidney failure patients.
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