Primary Sclerosing Cholangitis (PSC) Introduction Primary sclerosing cholangitis is a chronic disease of the “hepatobiliary system”. It is an inflammatory disease of the liver and gall bladder that leads to scar formation in the bile ducts that usually drain the bile from the gallbladder and passes it to the bowel to help digestion of fats. In primary sclerosing cholangitis, the bile ducts are usually blocked due to inflammation, scarring and fibrosis. Because of this the bile starts accumulating inside the