Dr. Vikram Chauhan is Available for Video Consultation. Click here To Book Your Slot Now !!
Meet Our Ayurveda Expert in Mumbai, india from 19th to 22nd March, 2021. For Details Click Here

Yakrit Plihantak Churna - Herbal Remedy for Liver Diseases

Yakrit Plihantak Churna (Yakrit means liver and Pliha means Spleen) is a herbal mixture of rare herbs to improve liver function. It helps the liver in clearing away the toxins. It regenerates the liver cells and prevents liver failure. It is useful herbal remedy fro fatty liver and liver cirrhosis, jaundice, liver damage due to alcohol, toxins and infection. The herb Katuki increases the bile production and excretion, whereas Makoye, Bhringraj and Kalmegh improve liver function. Punarnava and Bhumi amla regenerate liver cells and are useful in liver enlargement and inflammation. Giloy is immunomodulator and corrects liver metabolism. The combination of herbs is a wonderful remedy for all liver problems.

Herbs in Yakrit - Plihantak Churna

Yakritplihantak Churna is purely a herbal formulation without any chemicals added into it. The ingredients are frequently used in Ayurvedic system of medicine since 5,000 B.C. without any side effects.

Ayurvedic Energetics of this Product

Vata + , Pitta - , Kapha -

Indications of Yakrit - Plihantak Churna

Useful in Alcoholic liver disease, Enlarged & Fatty liver, High Cholesterol, Diabetes (Type I & II), Gall bladder Stones, Hormonal imbalances, Pitta (Excessive heat) disorders, Constipation.

Dosage and Methods of Administraton

1/2 to 1 teaspoonful twice daily, with plain water or fruit juice, after meals.

Ingredients in Yakrit - Plihantak Churna

S. No. Herb Used English Name Latin Name Quantity
1. Bhumi Amla Feather Foll Phyllanthus niruri 60 gm
2 Katuki Picrorhiza Picrorhiza kurrao 20 gm
3. Makoy Black Night Shade Solanum indicum 20 gm
4. Punarnava Hogweed Boerrhavia diffusa 20 gm
5. Kalmegh King of Bitters Andrographis paniculata 20 gm
6. Kaasni Chicory Cichorium intybus 20 gm
7. Sharpunkha Purple Tephrosia Tephrosia purpurea 20 gm
8. Bhringraj Eclipta Eclipta alba 20 gm

Yakrit Pllihantak has one of the rarest combination of Ayurveda herbs, which are very useful herbs for liver detoxification. This is an ancient and effective herbal formula for liver detox. It removes excessive fat from the liver and helps in regeneration of the damaged liver cells. It helps in so many metabolic and hormonal imbalances as liver is the seat of metabolism in the body. It is useful in disturbed hormones. That is why it is not only effective in liver disorders but also very effective in diabetes, with Madhumehantak Churna or Diabetes Support capsules.

The Ingredients in Yakrit Plihantak Churna are Unique in thier Action and Truly called 'Divine' Herbs:-

1. Bhumi Amla

Bhumi amla or Phyllanthus niruri is an extensively researched herb, found to be very effective natural treatment for Hepatitis B and other forms of Hepatitis. Phyllanthus niruri is grows in rainy areas, where humidity level is high. It is widely growing in tropical countries. Many age old herbal healers use Bhumi amla as a remedy for liver and kidney failure. It clears away the toxins from the body, detox the liver and brings down the SGOT and SGPT levels drastically within 3-4 months of regular use. The jaundice resolves within 15 days to 1 month and the bilirubin levels in the blood also come down remarkably. It regenerates liver cells and cures liver failure. So In my opinion, Yakrit Plihantak Churna must be used in almost every liver problem, for preventive as well as therapeutic use. It is also present in Kidney Support and Mutrakrichantak Churna for Kidney problems.

2. Katuki

It is known as Picrorrhiza kurro and is the most effective of all herbs to correct metabolism going on within the liver. It clears away the excessive fat deposited in liver, it increases the production and excretion of bile and is effective gall bladder cleanser. If regularly used, this can also clear away gall bladder stones. It aids in digestion, helps in fat metabolism. A very famous traditional medicine Arogyavardhni Vati also contains Kutki in it as its major ingredient. It is also present in Stholyantak Churna, which is highly effective natural solution to loose weight.

3. Makoy

Popular as Solanum indicum is a plant of Solanaceae family. It is a small growing weed like herb. It has amazing liver healing properties. It helps in bringing down alkaline phosphatase, useful in alcoholic liver damage, fatty liver, and hepatitis of all types. It also aids in regeneration of liver cells quickly.

4. Punarnava

Punarnava (Boerrhavia diffusa) is a natural diuretic herb. It removes excess of fat, water from within the body. It rejuvenates kidneys and liver, that's why the name is punarnava (Puna- means again, nava means new). It makes the body new again. Punarnava removes excessive fluid from the body, which is a feature of ascites due to liver or kidney failure. It also helps in regeneration of liver cells and natural remedy to balance albumin/globulin ration in the blood. It is also effective in urinary tract infections, nephrotic syndrome, nephrosis, kidney failure. It is also persent in Mutrakrichantak Churna which is useful in kidney and urinary problems.

5. Kalmegh

Kalmegh (Andrographis paniculata) is another herbal remedy for liver problems, fatty liver, hepatitis and alcoholc liver disease. People in India, use decoction of this herb as an effective natural solution for liver disesaes. It removes accumulated toxins from within the liver and contains alkaloids which help in immediate regeneration of damaged liver cells. It can be taken in routine without any side effects. A lot of farmers are now growing Kalmegh instead of wheat in India, as there is increased demand of this herb worldwide. No liver formula is consider complete without Kalmegh as its ingredient.

6. Kaasni

Kaasni - Cichorium intybus or Chicory bears unique divine healing power to care the worst liver and kidney failure as well. It can prevent going through dialysis and purifies the blood. Chicory is popular worldwide for its healing effect on kidney and liver. Kidney support or Mutrakrichantak Churna can be combined with Yakritplihantak Churna just to increase the dosage of Chicory. This combination is not only useful in kidney failure but also liver failure.

7. Sharpunkha

It is most effective herbal remedy for enlarged liver and spleen due to any reason. It is a natural alkaliser, decreases acidity and gas due to liver problem. It regenerates the capacity of the spleen to hold blood. It helps in regenration of liver cells.

8. Bhringraj

Eclipta alba is generally used for hair problems as an ancient ayurvedic remedy for hair loss. Bhringraj Oil is very famous for local application on hair to prevent hair loss. It has also been recommended in Ayurveda to use powder of the herb for liver diseases in many ancient texts. Latest research on Bhringraj indicats that it has amazing power to regenerate liver cells. It is helpful in alcoholic liver disease, fatty liver, liver damage due to any other reason or excessive toxins.

To buy Yakrit Plihantak Churna, please visit store.planetayurveda.com/products/yakrit-plihantak-churna

Real Testimonial

Dear Dr. Chauhan,

I am a diabetic with non-alcoholic fatty liver disease and, until a few weeks ago, liver enlargement. Because of this I had lost my appetite, I had nausea, a heavy sensation in my abdomen, skin rashes and multiple allergies. Because of my liver problems my blood sugar levels went higher and my diabetes was more difficult to control.

When I started taking Madhumehantak Churna for diabetes and Yakrit Plihantak Churna for liver ailments I noticed an immediate relief. After one month I had reduced my insulin requirements a great deal. My liver was no longer sligthly enlarged. My appetite was back and my nausea gone. My skin rashes cleared up completely and I have had no allergies since. My liver is not as fatty anymore. I do not dare to be without these products. They may have saved my life even.

Thank you very much - "40 year old female user in Sweden."- 19/06/07


Reference:- https://ijpsr.com/bft-article/standardization-of-yakrit-plihantak-churna-an-ayurvedic-polyherbal-formulation/


Manoj Kumar Pandey*1, G. N. Singh 1, Rajeev Kr Sharma 2 and Sneh Lata 3

Indian Pharmacopoeia Commission 1, Ghaziabad, Uttar Pradesh, India

Pharmacopoeia Laboratory of Indian Medicine 2, Ghaziabad, Uttar Pradesh, India

M. M. H. College 3, Ghaziabad, Uttar Pradesh, India


Most of the traditional systems of medicine are effective but they lack of standardization. So there is need to develop standardization technique. Central Council for Research in Ayurveda has given preliminary guidelines for standardization the conventionally used formulations. Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles, physical and chemical standards. This article reports on standardization of Yakrita Plihantak Churan a polyherbal Ayurvedic formulation used as hepatoprotective. Samples were collected from local market and were subjected standardized on the basis of organoleptic properties, physical characteristics, and physic-chemical evaluation. Microscopic characterization was compared with authentic ingredients as a reference. It was observed that commercial sample from market matched exactly with that of authentic standards after performing the standardization. The set parameters were found to be sufficient to evaluate the studied churna can be used as reference standard for the quality control/assurance purpose.


Standardization, Polyherbal formulation, Ayurveda and Physico-chemical Evaluation


Traditional system of medicine recommends various crude drugs for the treatment of hepatic disorder. The management of the liver disease is still challenge to modern medicine. No drug has been developed in modern system of medicine which may stimulate the liver function, protect it from damage or help in generation of hepatic cells. The only available drugs for the treatment for liver disorders are corticosteroids and immunosuppressive agents. But they are having many side effects.

Some of the important hepatoprotective polyherbal formulations are Liv-52, Livol, Arogyvarthini, Stimuliv, Terfroliv forte, Livit, Livomyn, and Adliv forte,1 etc. Yakrit Plihantak Churna (Yakrit means liver and Phila means spleen) is an herbal mixture of rare herbs to improve liver function.

It helps the liver in clearing away the toxins, regernates the liver cells and prevents liver failure. It is also useful in liver cirrhosis, jaundice, liver damage due to alcohol, toxins and infection. The herb Picrorhiza kurrao increase the bile productin and exerction, where as Solanum nigrum, Eclipta alba and Andrographis paniculata improve liver function.

Boerrhavia diffusa and Phyllanthus niruri regenerate liver cells and useful in liver enlargement and inflammation. Tephrosia purpurea and Cichorium intybus are immunodialator and corrects the liver metabolism. The combination of all eight herbs is a wonderful remedy for all liver problems. It contains excellent herbs for gall bladder clearing and clear gall stones naturally.

Standardization of herbal formulations is an essential factor in order to assess the quality, purity, safety and efficacy of drugs based on the concentration of their active principles. It is very important to establish a system of standardization for every plant medicine in the market, since the scope for variation in different batches of medicine is enormous.

Plant material when used in bulk quantity may vary in its chemical content and therefore, in its therapeutic effect very according to different batches of collection e.g. collection in different seasons and/or collection from sites with different environmental surroundings or geographical locations. The increasing demand of the population and the chronic shortage of authentic raw materials have made it incumbent, so there should be some sort of uniformity in the manufacture of herbal or Ayurvedic medicines so as to ensure quality control and quality assurance 2. The World Health Organization (WHO) has appreciated the importance of medicinal plants for public health care in developing nations and has evolved guidelines to support the member states in their efforts to formulate national policies on traditional medicine and to study their potential usefulness including evaluation, safety and efficacy 3.

In the present research work, an attempt was made to standardize Yakrit Plihantak Churna a polyherbal formulation containing of eight herbs (Table 1).


Botanical name Common Name English Name Family Quantity
Phyllanthus niruri Bhumi Amla Feather Foll Euphorbiaceae 60 gm
Picrorhiza kurrao Katuki Picrorhiza Scrophulariaceae 20 gm
Solanum indicum Makoy BlackNight Shade Solanaceae 20 gm
Boerrhavia diffusa Punarnava Hogweed Nyctaginaceae 20 gm
Andrographis paniculata Kalmegh King of Bitters Acanthaceae 20 gm
Cichorium intybus Kaasni Chicory Asteraceae 20 gm
Tephrosia purpurea Sharpunkha Purple Tephrosia Fabaceae 20 gm
Eclipta alba Bhringraj Eclipta Asteraceae 20 gm


Physico‐chemical studies like total ash, water soluble ash, acid insoluble ash, water and alcohol soluble extract, loss on drying at 105°C and successive extractive values by Soxhlet extraction method, microbial contamination and heavy metals analysis were carried out as per the WHO guide lines 3, Ayurvedic Pharmacopoeia 17 and Indian Pharmacopoeia 6. Preliminary phytochemical tests were performed as per the standard methods.

Plant material

The samples were collected from physician and manufacturers of Planet Ayurveda, Pvt. Ltd. (Formulation code CC1) which is being used as a liver protective Ayurvedic drug 18. For in house preparation, the ingredients were purchased from local raw material traders, which were authenticated by Pharmacopoeia Laboratory of Indian Medicine, Ghaziabad, India. (Formulation code CC2) and used as control. Polyherbal formulation consists of eight ingredients (Table 1).

Preparation of Polyherbal Formulation

All the ingredients (Table 1) were collected, dried and powdered separately, passed through 100 # sieve and then mixed together in specified proportions in a geometrical manner to get uniform mixture.

Standardization Parameters

The various standardization parameters studied were organoleptic properties, physico‐chemical investigations, determination of pH analysis, preliminary phytochemical analysis, fluorescence analysis, Heavy metal analysis, microbial evaluation, determination of moisture content, swelling factor, determination of viscosity, surface tension and density, determination of crude fat, and determination of physical characteristics of powder formulation.

Organoleptic Evaluation 4, 5

The organoleptic characters of the samples were evaluated based on the method described by Siddiqui et al. Organoleptic evaluation refers to evaluation of the formulation by color, odor, taste and texture etc (Table 2).


Organoleptic Characters Formulation code
Color Yellow Brown Brown
Odor Pungent Pungent
Taste Bitter Bitter

Physico-chemical investigations 6, 7:

Physico‐chemical investigations of formulations were carried out were the determination of extractive values and ash values (Table 3).

Determination of pH 8:

1% solution of Polyherbal formulation was prepared in distilled water and pH was determined using pH meter Orion digital pH meter (Table 3).


Parameters Formulation code
Total ash value (%w/w) 11.987 ± 0.19 13.483 ± 0.07
Acid insoluble ash value (%w/w) 0.9 40 ± 0.01 0.967 ± 0.03
Water soluble ash value (%w/w) 1.982 ± 0.26 1.340 ± 0.21
Alcohol soluble extractive value (%w/w) 25.539 ± 0.170 24.703 ± 0.080
Water soluble extractive value (%w/w) 24.510 ± 0.100 24.733 ± 0.154
Methanol soluble extractive value (%w/w) 15.21±0.12 14.3±0.35
Chloroform soluble extractive value (%w/w) 9.05±0.45 10.19±0.26
Ethyl acetate soluble extractive value (%w/w) 19.08±0.28 18.58±0.65
Petroleum ether soluble extractive value (%w/w) 11.08±0.58 11.84±0.23
Loss on drying at 1050(%w/w) 6.867 ± 0.06 6.667 ± 0.06
pH 1 % solution (%w/v) 5.85 ± 0.03 5.77 ± 0.03
pH 10% Solution (%w/v) 5.3 7 ± 0.06 4.83 ± 0.06
Crude fiber (gm) 0.27 ± 0.08 0.13 ± 0.04
Foreign organic matter Nil Nil

Note: Values are expressed as Mean ± SEM (n = 3)

Fluorescence analysis 4:

Fluorescence characters of powdered plant material with different chemical reagents were determined under ordinary and ultraviolet blight. 1mg of the Polyherbal sample was taken in a glass slide and treated with various reagents for the presence of their fluorescence characters under ultra‐violet lamp (Table 4).


Parameters Formulation code
Powdered drug Visible/day light Ultraviolet light Visible/day light Ultra violet light
Powder as such Dark brown Dark brown Dark brown Dark brown
Powder + FeCl3 Dark grey Greyish yellow Dark grey Dark grey
Powder + conc. HCl Orange yellow Greyish yellow Orange yellow Greyish yellow
Powder + 10% HNO3 Orange Yellow Orange Yellow
Powder + 10% K2Cr2O7 Yellow Green Yellow Green
Powder + 1 M NaOH Brownish yellow Green Brownish yellow Green
Powder + AgNO3 Buff brown Light brown Buff brown Light brown
Powder + conc. HNO3 Orange yellow Fluorescent yellow Orange yellow Yellow
Powder + conc. H2SO4 Orange Fluorescent green Orange Fluorescent green
Powder + Br2 water Brown Light brown Brown Brown
Powder + 5% H2O2 Brown Greyish green Brown Green
Powder + CCl4 Brown Dark brown Brown Brown
Powder + Methanol Blackish brown Greenish yellow Blackish brown Greenish yellow
Powder+CH3COOH Orange brown Dark green Orange brown Dark green
Powder + Xylene Grey Orange green Dark green Orange green
Powder + NH3 Yellowish brown Yellowish green Yellowish brown Yellowish green
Powder + I2 Blackish brown Grey Blackish brown Grey

Preliminary Phytochemical Analysis 9:

Preliminary qualitative phytochemical analysis of all the extracts was carried out on methanolic extract by employing standard conventional protocols (Table 5).


Parameters Formulation code
Glycosides + +
Tannins + +
Flavonoid + +
Carbohydrates + +

Note: + indicates presence − indicates absence

Determination of Moisture Content and Swelling Factor 10:

Moisture content was determined by loss on drying (LOD) method. 5gm of the weighted quantity of the drug was taken and kept in oven at 1050C till a constant weight was obtained. Amount of moisture present in the sample was calculated as reference to the air dried drug (Table 3).

Swelling factor is estimated for the amount of mucilage present in the drug. The technique has been accepted as an official method for evaluation by various pharmacopoeias. One gram of the Polyherbal was taken and kept for 24 hours in a graduated, stoppered cylinder, in contact with the water up to the mark of 20 ml. After 24 hours the increase in volume was noted.

Determination of Physical Characteristics of Powder Formulation 11, 12:

Physical characteristics like bulk density, tap density, Hausner's ratio, and Carr's index were determined for different formulations the term bulk density refers to packing of particles or granules. The volume of packing can be determined in an apparatus consisting of graduated cylinder mounted on mechanical tapping device (jolting volumeter) that has a specially cut rotating can. 100 grams of weighed formulation powder was taken and carefully added to cylinder with the aid of a funnel.

The initial volume was noted and sample was then tapped until no further reduction in volume was noted. The initial volume gave the bulk density value and after tapping the volume reduced, it gives the value of tapped density.

Hausner's ratio is related to inter particle friction and as such can be used to predict the powder flow properties. Carr's index is a method of measuring the powder flow from bulk density (Table 6).


Parameters Formulation code
True density (1% soln) 0.564 ± 0.010 0.946 ± 0.010
Bulk density (gm/ml) 0.392 ± 0.018 0.488 ± 0.019
Porosity % 88.1 ± 0.012 91.0 ± 0.026
Angle of Repose 42° ± 0.24 41° ± 0.31
Viscosity (1% soln) 1.02cp 1.05cp
Surface tension (1% soln) 49.5 50.2
Fluff density (gm/ml) 0.392 ± 0.010 0.488 ± 0.014
Tapped density (gm/ml) 0.587 ± 0.007 0.647 ± 0.001
Hausner's ratio 1.371 ± 0.005 1.328 ± 0.006
Carr's compressibility index 19.25 19.95

Determination of Crude Fat 10:

2 g of moisture free Polyherbal with petroleum ether in Soxhlet extractor, for 6 h till a drop taken from the drippings left no greasy stain on the filter paper. After boiling with petroleum ether, the residual petroleum ether was filtered and filtrate was evaporated in a pre weighed beaker. Increase in weight of beaker gave the crude fat.

Heavy Metal Analysis 11: (Table 7)

Preparation of Samples by Acid Digestion Method:

Accurately weighed 2 g of sample was taken in Kjeldahl flask. Acid mixture of HNO3: HClO4 (4:1) was added in the flask and heated continuously till the solution is colorless. The sample was then transferred in a 25 ml volumetric flask and the volume was made-up with distilled water.

Reagent blank was synchronously prepared according to the above procedure. The standards of Lead (Pb), cadmium (Cd), arsenic (As) and mercury (Hg) were prepared as per the protocol in the manual and the calibration curve was developed for each of them.


Then samples were analyzed for the presence of Pb, Cd, As and Hg using Atomic Absorbance Spectrophotometer (AAS) 6300 (by SHIMADZU).


Heavy Metals Formulation code

Microbial Analysis 6:

Microbial analysis was carried for determination of microbial contamination as per procedures of Indian pharmacopoeia 6 2010 and WHO Guideline 3. The test included total bacterial count, total yeast and mould count, Identification of specified organisms such as Escherichia coli, Salmonella sp., Staphylococcus aureus and Pseudomonas aeruginosa (Table 8).


Parameters Formulation Code
Salmonella typhi
Pseudomonas aeruginosa
Staphylococcus aureus
Total bacterial count Less than 1000cfu/gm Less than 1000cfu/gm
Total yeast and mould count Less than 100cfu/gm Less than 100cfu/gm

Quantitative Estimation of Tannins 13:

1 gm of powdered drug was refluxed in 100 ml of 70% aqueous acetone for 2 hours followed by filtration. The filtrate was concentrated and partitioned with solvent ether (3 times) and then with n- butanol previously saturated with water (table 9). The n- butanol soluble portion was dried over water bath until constant weight. Total tannin content was calculated by formula:

% w/w total tannin content=

Weight of n- butanol fraction in gm X 100

Weight of sample in gm

Quantitative estimation of Flavonoids 13:

1gm of powdered drug was boiled in 100 ml methanol for 1 hour followed by filtration. 1ml of filtrate was placed in 10ml volumetric flask. 3ml methanol and 0.3 ml NaNO2 were added in the flask. 3ml of AlCl3 was added after 5min. 2ml of 1M NaOH was added and the net volume was made to 10 ml with methanol and absorbance was measured against a blank at 510nm (table 9).

The total flavonoids content was calculated using following equation.

A = 0.01069c - 0.001163

A = absorbance, c = flavonoid content μg/g.


Parameters Formulation code
Total Flavonoid content (μg/g) 5.2 ± 0.2 5.5± 0.1
Total Tannin content (%w/w) 5.1 ± 0.1 6.3 ± 0.4


As a part of standardization procedure, both the samples (Formulation code CC1 and CC2) were tested for relevant physical and chemical parameters, and also subjected to microbial screening through quality control measures. Botanical parameters revealed that dark brown in color, with a pungent odor, bitter taste, and fine texture (Table 2).

Results of quantitative analysis for Total ash, Acid insoluble ash, Water soluble ash, Alcohol soluble extractives, Water soluble extractive ,Hexane soluble extractive, Chloroform soluble extractive, Ethyl acetate soluble extractive, Particle size (100 mesh), Loss on drying at 105º C ,pH (1% and 10% aq. Soln), Crude fat were calculated and results were shown (Table‐3). Ash value is useful in determining authenticity and purity of drug and also these values are important quantitative standards. Percent weight loss on drying or moisture content was found to be 6.8% w/w. The less value of moisture content could prevent bacterial, fungal or yeast growth.

The results of fluorescent studies of the powdered plant material using different chemical reagents were studied and a given in (Table‐4). Fluorescence is an important phenomenon exhibited by various chemical constituents present in plant material. If the substances themselves are not fluorescent, they may often be converted into fluorescent derivatives by reagents hence some crude drugs are often assessed qualitatively in this way and it is an important parameter of pharmacognostical evaluation.

Phytochemical analysis revealed the presence of glycosides, carbohydrates, saponins, tannins, and flavonoids (Table 5 and 9). Density, viscosity and surface tension of the polyherbal formulation (1% aq.) were determined and results were tabulated (Table‐6). Physical properties of the polyherbal formulation, like bulk density, tap density, Carr's compressibility index, Hausner's ratio, were determined and results were tabulated (Table 6).

Swelling factor of the polyherbal formulation was determined but it does not show appreciable amount of mucilage to be estimated, indicating the presence of very less amount, but the phytochemical screening reveals the presence of mucilage in the polyherbal formulation. Various microorganisms like Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi contaminate herbal drugs and cause serious health hazards 14.

For detection of such microorganisms, colonies obtained on specific media were subjected to suitable microbial tests along with pure strains to detect their presence or absence. The results obtained (Table 8) revealed the absence of these microorganisms thereby confirming the non toxic nature of the formulations.

Heavy metals may be present in crude drugs through atmospheric pollution and through the soil. Moreover minerals and metals are also used in preparing Ayurvedic formulations. However, heavy metals have been associated with various adverse effects 15 including status epilepticus, fatal infant encephalopathy, hepatotoxicity, congenital paralysis and deafness, and developmental delay. Many case studies have reported serious adverse conditions due to heavy metals in Ayurvedic and other herbal drugs 16.

Hence, heavy metals need to be detected in such preparations. In this study, all the samples tested negative for the presence of heavy metals (Table 7), thereby further confirming the non toxic nature of the preparation. Hence, Yakrit Plihantak Churna is a safe polyherbal formulation and is free from any toxic materials. The results obtained in this study may be considered as tools for assistance to the regulatory authorities, scientific organization and manufacturers for developing standards.


Authors are thankful to Indian Pharmacopoeia Commission Ghaziabad (U.P.) providing necessary facilities to complete this work.


  1. Savadi VR, Manjunath KP, Khanalakar MA, Patel MA. Comparative Study of Liv Compound Syrup and Herbal Formulations for Hepatoprotective Activity. J of Pharmacy Research 2009; 2(4):733-737.
  2. Chakravarthy BK. Standardization of Herbal Products. Ind. J. Nat. Products 1993; 9: 23–26.
  3. WHO. Quality Control Methods for Medicinal Plant Materials. Geneva: AITBS Publishers and Distributors, Delhi; 2002.p. 65–67.
  4. Agarwal SS. Herbal Drug Technology. Hyderabad: University Press (India) Pvt Ltd; 2007. 625–679.
  5. Siddiqui A, Hakim MA. Format for the Pharmacopoeial Analytical Standards of Compound Formulation, Workshop on Standardization of Unani Drugs, (appendix), (Central Council for Research in Unani Medicine, New Delhi, January); 1995.p.24–25.
  6. Indian Pharmacopoeia, (Ministry of Health and Family Welfare, Gov­ernment of India, New Delhi); 2010; Vol I: p.10-146.
  7. Evan's WC, Trease G E. Pharmacognosy, (Elsiever Publication); 2007:15, p. 96–103..
  8. Mohapatra P, Shirwaikar A, Ram HN. Standardization of Polyherbal Formulation. Pharmacog. Magazine.2008; 4:65–69.
  9. Khandelwal KR, Practical Pharmacognosy, (Nirali Prakashan.) Pune; 2006:16:149–161.
  10. Mukherjee PK. Quality Control of Herbal Drugs, 1st ed., Business hori­zon, New Delhi. 2002;356:187–195.
  11. Lohar DR. Protocol for Testing of Ayurvedic, Siddha & Unani medicines. Government of India, Department of AYUSH, Ministry of Health & Family Welfare: Pharmacopoeial laboratory for Indian medicines, Ghaziabad.2007:47-52.
  12. Martin Alfred. Physical Pharmacy (Lippincott Williams and Wilkin, Maryland). 2001; 4: 442–448.
  13. Jain S, Koka S, Gupta A, Barik R, Malviya N.Standardization of "Chopchiniyadi Churna": An Ayurvedic Polyherbal Formulation.Phcog J.2010;2:5:60-64.
  14. Jain S, Srivastava S, Barik R, Kumar P. Standardization of 'Dashamu­larishta': A Polyherbal Formulation. Phcog J 2009; 1:3:215–220.
  15. Dwivedi SK, Dey S. Medicinal Herbs: A Potential Source of Toxic Metal Exposure for Man and Animals in India. Arch Environ Health.2002; 57:229–231.
  16. Moore C, Adler R. Herbal Vitamins: Lead Toxicity and Develop­mental Delay. Pediatrics.2000; 106: 600–602.
  17. The Ayurvedic Pharmacopeia of India, Govt. of India, Min. of Health and Family Welfare, Department of Ayurveda, Yoga and Homoeopathy(Ayush),New Delhi.2001;Part-1;Vol.-1-5;1 edition.
  18. Kumar CH, Ramesh A,Kumar JNS, Ishaq MB. A Review on Hepatoprotective Activity of Medicinal Plants.Int.J. of Pharma.Sci. and Res.2011;2(3):501-515.

Knowledge Base

Diseases A-Z

View All

Herbs A-Z

View all
Let’s Connect
close slider

    Leave a Message

    error: Content is protected !!
    WhatsApp Live Chat with our Experts